The God of Abraham, Isaac, and Jacob

The story of Genesis begins with God giving immense responsibility and authority to humanity. And what does humanity do with its responsibility and authority, its privileged place in the world? As far as back as we can tell, we redefine good and evil on our own terms to our own self-advantage. We're stupid, we're short-sighted, and we're selfish. And so we ruin God's good world. What is the God of the Bible's response to a world who are ruining each other and ruining his world?