For a long time, exercise scientists said that eight to 12 repetitions per set is optimal range for muscle hypertrophy. Brad Schoenfeld did much of this work and showed it's pretty much equal from anywhere between five sets up to 30sets if other things are equated for. The reps in reserve has to basically, if you get pretty close to failure, not failure necessarily, but exactly. At the end of 30, you need to be hurting as much as you would be at the end of seven. It's very hard because you're going to start hurting at like 15. Much sooner.

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