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The Doyen Of Behavioural Genetics On Untangling Nature And Nurture — Robert Plomin

The Joe Walker Podcast

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The Curse of Dimensionality Is the Biggest Problem

Until recently, you could be diagnosed as both by polar and schitsophrenic. But the first time we found jeans, about ten years ago, for scitsophrania, the shock was, every gean you find for scits phrania also predicts by polar. So even at that very specific dana level, there's a lot of genetic overlap. Most of the genetic effects are general rather than specific. I've heard people say that because of the curse of dimensionality, or the curse ofdimensionality, cripples our ability to make inferences beyond monogenic effects. Yes, it's the biggest problem. You know, when you say geanetic to

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