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Episode 20 - STEMI

The Curious Clinicians

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Transmural Myocardial Infarctions - STEMI or ST Elevation?

The inciting event, at least from like an electrocardiographic perspective, is the mitochondria of ischemic myocardial cells are unable to generate enough ATP. So as a result, during ischemia, you have more potassium exported from the myocyte on an ongoing basis. This leads to faster ventricular depolarization of those cells relative to non-ischemic well-perfused myocytes. The electrical cycle in ischemic cells, you know, it becomes shorter as a result. In this episode, we'll see why that's relevant and what happens when you have different charges near each other.

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