The Pain Center of the Brain

The brain itself is the region where these signals are processed in a particular way to give rise to the sensation of pain. Some regions that are disproportionately more active during perceptions of pain than at other times. Activating them doesn't necessarily generate pain, and people with congenital insensitivity to pain have these regions activated, but don't feel the pain. There's some missing ingredient here, it seems, that we don't understand yet.