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Feb 24 2023 This Week in Cardiology

This Week in Cardiology

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Clear Outcomes Trial - Bempedoic Acid

Bempedoic Acid is a once daily oral prodrug that is activated in the liver and it inhibits action of ATP citrate lyase which acts upstream from HMG OA reductase to molecule blocked by statins. Clear Outcomes trial with 14,000 statin intolerant patients met its primary endpoint of first occurrence of CVDath MI stroke or coronary revascularization. JAMA published a short trial in 700 patients which also showed that the drug reduced LDL cholesterol by a statistically significant 18% over placebo.

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