Navigating Mendelian Randomization in Lipidology

This chapter explores the complexities and debates of Mendelian randomization studies in lipidology, particularly concerning LDL cholesterol and cardiovascular disease. The speakers discuss genetic influences on LDL levels, the implications of various genes like PCSK9 and CETP, and the limitations of relying on such studies for conclusive evidence. The conversation emphasizes the importance of critiquing underlying assumptions and seeking more empirical data to better understand cholesterol's role in health outcomes.