My guest on the show today is David A. Sinclair, Ph.D, a tenured Professor of Genetics at Harvard Medical School, he is best known for his work on genes and small molecules that delay ageing, including the Sirtuins, NAD precursors, Resveratrol and other epigenetic modifiers.
He has received many honours including a feature on TIME magazine’s list of the “100 most influential people in the world” and this podcast episode about how to treat and reverse ageing will give you a glimpse into why he is so deserving.
On the show we talk about:
- The hallmarks of ageing and why to distinguish it as a disease
- Instead of trying to tackle each one of the 8 central tenants of ageing, how Prof is looking at the epigenome
- Sirtuins and their role in ageing, DNA repair and gene expression
- AMPK, MTor, Sirtuins as regulators of lifespan and defence pathways
- Methods of fighting ageing and activating the body’s natural defence systems
- Energy restriction, aerobic exercise, sauna and cold shock therapy
- energy restriction, exercise triggering hypoxia, sauna, cold shock therapy,
- NAD and NAD precursors, Metformin, rapamycin and resveratrol as molecules that can improve ageing
- Why we need to treat ageing like a disease, which forms the foundation of multiple diseases. If we cure ageing, we cure a lot.
- The ethical considerations of increasing lifespan
Do check out David’s work and his latest book - Lifespan - Why We Age and Why We Don’t Have To.
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