Intro

This chapter delves into the complexities of aging across different organ systems and presents System Age as a tool for assessing internal health. It also highlights a home blood test that informs listeners about their physical well-being and features insights from a plastic surgeon on advanced surgical and regenerative techniques.

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Episode notes

Wrinkles are just the surface. This episode reveals what’s really happening beneath your skin and how to reverse it using stem cells, regenerative medicine, and the most advanced techniques in plastic surgery and aging. You’ll learn how to improve facial skin tightening, reduce inflammation, and trigger deep skin rejuvenation with stem cells, red light therapy, and targeted procedures that actually work.

Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey shares his personal journey through weight loss and skin excess, including why he had 28 inches of skin removed and how he rebuilt facial structure using stem cells and longevity protocols. He’s joined by Dr. Victor Urzola, a globally recognized expert in plastic surgery and aging, known for pioneering biohacking skin health techniques, cutting-edge facial reconstruction, and legalizing therapeutic stem cell use in Costa Rica.

Together, they expose the hidden causes of wrinkles and aging, from mitochondrial slowdown to ligament laxity and collagen depletion. They also unpack the science behind breast implant health risks, silicone toxicity syndrome, and why thousands of women experience hormonal, neurological, and metabolic symptoms related to their implants. Dr. Urzola explains how explant surgery can improve hormone balance, sleep, HRV, metabolism, and even libido. You’ll also hear how cosmetic procedures interact with HPA axis function and how skin and brain health are more connected than you think.

This episode is a must for anyone serious about biohacking, skin optimization, stem cells and longevity, and functional medicine. Dave also breaks down his recovery stack, including exosomes, red light therapy, collagen cycling, nootropics, and how cosmetic procedures can be used to enhance—not just appearance—but total human performance.

You’ll learn:

• The real root causes of wrinkles and sagging skin

• How to use skin rejuvenation with stem cells for long-term results

• Signs of silicone toxicity syndrome and what to do about it

• Why cosmetic procedures impact hormone health and libido

• The most effective strategies for facial skin tightening and recovery

• How to approach breast implant health risks with functional medicine thinking

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.

Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.

SPONSORS:

Generation Lab | Go to https://www.generationlab.com/ use code Dave20 for $20 off.
Qualia | Go to https://www.qualialife.com/dave15 to get an additional 15% off subscriptions.
fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.
Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.
Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order.

Resources:

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

• Dr. Urzola’s Website: https://drvictorurzola.com/en/

• Danger Coffee: https://dangercoffee.com

• Dave Asprey’s Website: https://daveasprey.com

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey

• Upgrade Labs: https://upgradelabs.com

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com

• Own an Upgrade Labs: https://ownanupgradelabs.com

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com

Timestamps:

• 00:00 Trailer