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Freely Filtered 052: Acetazolamide for Acute Decompensated Heart Failure (ADVOR)
Freely Filtered, a NephJC Podcast
Inpatient Acute Decompensated Heart Failure Intervention - Does It Improve Mortality?
The primary endpoint was consistent across subgroups as well, but all favored acetazolamide for secondary outcomes. They called out in their discussion that the patients on the higher dose of diuretics had less benefit from acetazolamia. So these things weren't pre-specified or powered so they don't have peace for interaction,. But that does seem to be something you can observe that if you're on higher doses of diuretic, it seems to probably not as beneficial. These are all exploratory ideas.
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