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Ep. 33: Skin Repair Featuring Dr. Marius Wernig

The Stem Cell Podcast

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Advancements in Skin Gene Therapy

This chapter explores a severe skin condition caused by dysfunctional anchoring fibrils in newborns, discussing complications like mitten deformities and impaired wound healing. It highlights the potential of gene therapy using induced pluripotent stem cells (iPSCs) for autologous grafting, emphasizing the role of the RB gene in enhancing cell reprogramming and pluripotency. The conversation contrasts the challenges of brain diseases with the more accessible and observable nature of skin therapies, underlining the advancements in developing personalized treatments for skin disorders.

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