When someone has insulin resistance, they are causing their own cognitive decline by multiple mechanisms. You're really ticking most of the boxes to give yourself cognitive decline when you have insulin resistance. A sudden loss of estradiol, as was shown by Mayo Clinic group years ago, if you have a sudden loss of Estradiol at the age of 40 and get HRT then you are doubling your risk for Alzheimer's. If you can optimize those four main groups, you are going to do a tremendous amount with preventing and reversing cognitive decline.

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