How Do Benzodiazepines Work on GABA-A Receptors?

Today, we are talking about a very popular, yet controversial class of medications - the Benzodiazepines . Let's look at their mechanism of action, clinical indications, pharmacology, risks, withdrawal syndromes, and prescribing guidance. And of course, we'll be tackling the question: what are the risks and benefits of long-term use?

References:

• https://pubmed.ncbi.nlm.nih.gov/30098211/

• https://pubmed.ncbi.nlm.nih.gov/32252539/

• https://nida.nih.gov/research-topics/trends-statistics/overdose-death-rates

• https://aapp.org/guideline/benzo

• https://pubmed.ncbi.nlm.nih.gov/40526204/

• https://pmc.ncbi.nlm.nih.gov/articles/PMC6097846/

• https://www.ncbi.nlm.nih.gov/books/NBK470159/

• https://www.cambridge.org/core/journals/advances-in-psychiatric-treatment/article/benzodiazepines-for-anxiety-disorders-maximising-the-benefits-and-minimising-the-risks/43A366723CD1B3616BAB08F69FF65A88