When you give testosterone, these hormones will go up or down depending on a number of factors. Some men are very strong five alpha reductase producers and they're going to make a lot of DHT. This is responsible for one of the side effects of testosterone, which is hair loss. A drug known as nastrosol can be used to block estradiol conversion if it's too high. But I personally am not a big fan of using it because I find you don't need to use it in most men.

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