The Evolution of Genome Rearrangements

Chromosome rearrangements are typically not an advantage during miosis and the formation of gametes. Small mutations that re shuffle the gean order within chromosomes can still occur, but broken or fused chromosomes tend to be dead ends. Unless a chromosome rearrangement con s a big functional advantage, it's inherently hard for the rearrangement to spread. The processes by which they move are just slow, on a scale of 500 million years.