Combining Antidepressants: Mirtazapine and Venlafaxine

This chapter explores the therapeutic combination of mirtazapine and venlafaxine for treating depression when SSRIs fail, highlighting their effects on serotonin and norepinephrine. It also discusses the efficacy and safety of nefazodone as a monotherapy, its unique benefits in sexual dysfunction, and critical safety considerations including hepatotoxicity.