The Role of Training Variables in Muscle Damage

Historically, it was believed by many people that muscle damage was actually a driver and a stimulus itself for hypertrophy. And now I think it's more widely accepted that when muscle damage happens, it's going to detract from hypertrophy by taking its resources away. So we have an interference effect that can be caused at the central nervous system level due to short risk periods or low frequency fatigue. We also have excitation contraction coupling failure where motor neurons become somewhat fatigued through repeated muscular contraction sending those signals over and over and over again. This is one of our four major kind of mechanisms that's going to limit the benefit of additional sets in the workout.