SSRIs, Serotonin Spillover, and Reward

They discuss SSRIs pushing serotonin into dopamine terminals and how that can blunt reward signaling.

Play episode from 01:11:10

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Episode notes

Dr. Read Montague, PhD, is a professor and director of the Center for Human Neuroscience Research at Virginia Tech’s Fralin Biomedical Research Institute and an expert in how dopamine and serotonin shape human learning, motivation and decision-making. We discuss how they impact focused effort in the context of short- and long-term goals of all kinds. Also, how SSRIs and low-effort, high-engagement activities reduce the rewarding properties of dopamine, and how AI algorithms are revolutionizing understanding of the brain.

Episode show notes are available at hubermanlab.com.

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Timestamps

(00:00:00) Read Montague

(00:02:54) Dopamine, Motivation & Learning

(00:08:49) Reward Prediction Error, Expectations

(00:12:24) Sponsors: David & Joovv