The Interplay of Caffeine, Melatonin, and Tryptophan in Brain Chemistry

Not a lot of authors go from spending their early twenties homeless and addicted to cocaine to becoming one of the world’s leading researchers on the neuroscience of addiction. But Dr. Judith Grisel, in her new book Never Enough: The Neuroscience and Experience of Addiction (Doubleday, 2019), uses her personal story to illuminate the ways in which the brain, in collusion with social and biological factors, makes addiction possible. In our discussion, Grisel outlines the effects of different drugs, explains the “three laws of psychopharmacology,” and wonders if we’ll ever find medicine’s “holy grail” – a cure for addiction.

Emily Dufton is the author of Grass Roots: The Rise and Fall and Rise of Marijuana in America (Basic Books, 2017). A drug historian and writer, she edits Points, the blog of the Alcohol and Drugs History Society.

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