Artificial Intelligence and Drug Safety

Can Medicine Move To Animal-Free Testing?

Before a new drug can begin clinical trials in humans, it gets tested on animals. But things are changing. Late last year, Congress passed the FDA Modernization Act 2.0, which cleared the way for new drugs to skip animal testing. Can we expect to phase out animal testing altogether? Is it safe? And what technologies might make that possible? Guest host Flora Lichtman talks with Dr. Thomas Hartung, director of the Johns Hopkins Center for Alternatives to Animal Testing, to get a broader picture of alternatives to animal testing.

 

Capturing Carbon With Tasty Fungus

This week, a report from the Intergovernmental Panel on Climate Change brought dire warnings about our planet’s climate future and an alert that drastic action is needed—now—to avoid catastrophe. One action the report recommends involves an overhaul of our food production systems to decrease their carbon impact.

 

Writing in the Proceedings of the National Academy of Sciences, researchers suggest one possible way of sequestering some carbon dioxide might be cultivating certain kinds of edible mushrooms on land that has already been cultivated for agroforestry. The researchers are working with Lactarius deliciosus, commonly known as the saffron milk cap or red pine mushroom, but other species are possible as well. These mycorrhizal fungi live in a symbiotic relationship with the roots of the trees, increasing biomass and storing more carbon, while producing food on land that might have otherwise been used only for trees.

In certain climates and with certain trees, these fungi can actually be a carbon-negative source of protein. However, to produce a pound of protein currently requires a lot of land and effort. The researchers are working to make forest fungal farming easier, and to expand the approach to a wider range of trees. SciFri’s Charles Bergquist talks with Dr. Paul Thomas, author of that report and research director at the company Mycorrhizal Systems, a company that helps farmers grow truffles. He’s also an honorary professor in the University of Stirling’s Faculty of Natural Sciences in the UK.

 

Whiskey Distillery On The Rocks After Fungus Spreads

Lincoln County, Tennessee has been overcome by an unwelcome guest: whiskey fungus. It covers everything from houses and cars to stop signs and trees, and no amount of power washing seems to make it go away. Why has whiskey fungus attached to this small town? It feeds on ethanol from the famed Jack Daniel’s distillery, which is in a neighboring county.

Lincoln County isn’t the first place to encounter this problem. Whiskey fungus was first documented in 1872 by a French pharmacist named Antonin Baudoin. Baudoin noted how mold caused distillery walls in Cognac to blacken, a phenomenon that has since been seen near distilleries across the world. The fungus was not given a name until 2007, when it was dubbed Baudoinia compniacensis, named for Antonin Baudoin. Joining guest host Flora Lichtman is James A. Scott, PhD, professor of public health at the University of Toronto in Toronto, Ontario. Scott has studied whiskey fungus for over two decades, and gave it its scientific name.

 

NASA’s New Science Head Sees A Bright Future

Last month, NASA announced Dr. Nicola Fox as the agency’s new scientific leader. Fox is taking on a critical role at NASA, shaping the agency’s science priorities and overseeing roughly 100 missions, with a budget of $7.8 billion. The portfolio includes space science from astrophysics and Earth science, covering the planets in our solar system to exoplanets far beyond. Previously, she was the director of the heliophysics division at NASA, which studies the Sun and its role in the solar system. SciFri senior producer Charles Bergquist talks with Dr. Nicola Fox, associate administrator for the Science Mission Directorate for NASA, about her new position, career path, and plans for science at NASA.

 

 

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