In this chapter, they discuss different targets for drug interventions as anti-inflammatories. They explain that neurotransmitters like serotonin and substance P are not pain specific or inflammatory specific, so blocking them would have wider effects on the body. They mention the drug ketamine, which is an NMDA antagonist that stops glutamate from binding, but note that it has other effects beyond inflammation and pain relief. They also mention drugs targeting substance P, but state that they are not currently effective.