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JAMA Oncology : Lynch Syndrome and Somatic Mismatch Repair Variants in Pancreas Cancer

JAMA Network

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Intro

This chapter examines a study on Lynch Syndrome and somatic mismatch repair variants in pancreatic cancer, highlighting key clinical genomic features and treatment outcomes. It emphasizes the significance of MSI high status as a biomarker for predicting responses to immune checkpoint blockade therapy and discusses the complexities of mismatch repair deficiency.

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