Understanding Gender and Sex in Biomedical Research

Ever since scientific enquiry began, people have focused mainly on men, or if studies involve animals, on male mice, male rats or whatever it may be. And this has led to gaps in scientists’ understanding of how diseases, and responses to treatment, and many other things might vary between people of different sexes and genders.

These days, mainly thanks to big funders like the NIH introducing new guidelines and mandates, a lot more scientists are thinking about sex and, where appropriate, gender. And this has led to a whole host of discoveries.

But all this research is going on within a sociopolitical climate that’s becoming increasingly hostile and polarized, particularly in relation to gender identity. And in some cases, science is being weaponized to push agendas, creating confusion and fear.

It is clear that sex and gender exist beyond a simple binary. This is widely accepted by scientists and it is not something we will be debating in this podcast. But this whole area is full of complexity, and there are many discussions which need to be had around funding, inclusivity or research practices.

To try to lessen fear, and encourage clearer, less divisive thinking, we have asked three contributors to a special series of opinion pieces on sex and gender to come together and thrash out how exactly scientists can fill in years of neglected research – and move forward with exploring the differences between individuals in a way that is responsible, inclusive and beneficial to as many people as possible.

Read the full collection: Sex and gender in science

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