Bony Cancer Pain - What Causes Bony Pain in Bones?

One of the types of a bone pain that is described in patients who have cancer is thi sort of vague, escalating overtime pressure. So we know from these kinds of experiments that increasing the pressure inside of just the bone marrow will cause pain. And also noxious stimuli inside of the bone marrow would do the same thing. But it's very challenging to like, reduced the actual temperature inside of a living animal’s bone a and were not able to do that.