People who drink regularly experience changes in their hypothalamic pituitary adrenal axis that result in more cortisol, more of this so-called stress hormone being released at baseline when they are not drinking. Alcohol can go anywhere in the brain and has effects on the hypothalamus which houses neurons responsible for some incredible aspects of our behavior and mindset. People who drink just one or two drinks per night could be somebody with a predisposition to alcoholism.

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