Discover a new gene editing technology, a base editor that offers precision with fewer errors compared to CRISPR-Cas9. Delve into discussions on the potential of AI in developing similar solutions and the benefits of open research tools, concluding with updates on the Nature Briefing and podcast connectivity.
In this episode:
00:46 Using genomics to explain geographic differences in cancer risk
The risk of developing cancer can vary hugely depending on geographic region, but it’s not exactly clear why. To get a better idea, a team has compared the genomes of kidney cancers taken from people around the globe. They reveal a link between geographical locations and specific genetic mutations, suggesting that there are as-yet unknown environmental or chemical exposures in different locations. They hope this work will inform public health efforts to identify and reduce potential causes of cancer.
Research reveals that the extinct ‘sabre-toothed salmon’ actually had tusks, and a common fungus that can clean up both heavy-metal and organic pollutants.
09:55 How disrupting a male mouse’s microbiome affects its offspring
Disruption of the gut microbiota has been linked to issues with multiple organs. Now a team show disruption can even affect offspring. Male mice given antibiotics targeting gut microbes showed changes to their testes and sperm, which lead to their offspring having a higher probability of severe growth issues and premature death. Although it’s unknown whether a similar effect would be seen in humans, it suggests that factors other than genetics play a role in intergenerational disease susceptibility.