Virtual library of LSD-like drugs could reveal new antidepressants
Nature Podcast
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Psychedelic Drugs - What Are They All About?
The team synthesized a handful of these chemicals in the real world. They went through an iterative process of testing them and tweaking them until they whittled down to just two. Brian says he expected that these two molecules would have psychedelic effects, like other tetrahydroperidine containing drugs such as LSD. But they don't at up to very high doses,. Despite the fact that they got into the brain at very high levels and had basically good drug-like properties. Because most but not all drugs that activate this receptor are psychedelic.
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