The Structure of Lorelatt Nib

Lorelatt nib is a macrocyclic or a circular molecule which means it's more compact and what that allows it to do is to get into the alp binding pocket even in the context of certain mutations. Lorelatt nib also facilitates the entry into the CNS. That's interesting i think i've read something about CSF levels is my right has happened looked at but yes so in the phase one to study there were some patients who had CSF levels done and and you do get pretty good CSF concentrations. And that translates clinically to responses in leptumen and geodisease and some of those responses can really be quite durable even in patients who progressed on second