The Role of Therapeutic Drug Monitoring in Beta-Lactam PKPD Optimization

Historically, because beta-lactams have been considered to be so safe and have a broad therapeutic window, TDM was really not routinely performed. Now with greater focus on precision dosing and personalized medicine, I think it's no longer justifiable to say that we can continue to dosebeta-lactam the way we always have using standard package and sedoses. The second role of TDM is to optimize the PKPD of beta- lactams. Given what we know about PK variability, particularly in critically ill patients, I think our ICU patients should probably be prioritized for TDM. We now know through a lot of extensive research primarily done by many of the