2min chapter

Huberman Lab cover image

Dr. Peter Attia: Improve Vitality, Emotional & Physical Health & Lifespan

Huberman Lab

CHAPTER

Alzheimer's - Is the APP Mutation Cleaved?

The two hallmarks of Alzheimer's histopathologically would be plaques and tangles. The link between the APP and whether or not one develops genes for a related to APP is just what you were describing and risk for Alzheimer's. People with the APP mutation, I think have one extra cleavage site. They result in one extra Cleavage of amyloid and then it misfolded. That also predisposes them to the neurofibrillary tangles.

00:00

Get the Snipd
podcast app

Unlock the knowledge in podcasts with the podcast player of the future.
App store bannerPlay store banner

AI-powered
podcast player

Listen to all your favourite podcasts with AI-powered features

Discover
highlights

Listen to the best highlights from the podcasts you love and dive into the full episode

Save any
moment

Hear something you like? Tap your headphones to save it with AI-generated key takeaways

Share
& Export

Send highlights to Twitter, WhatsApp or export them to Notion, Readwise & more

AI-powered
podcast player

Listen to all your favourite podcasts with AI-powered features

Discover
highlights

Listen to the best highlights from the podcasts you love and dive into the full episode