The ADELTA fiber stimulates the A-delta and C-fibers. It can be used to stimulate nociceptus or... Or they can change the threshold so it's easier for the nocicePTus to fire off. So what happens when you damage vascularized tissue mat by definition? Inflammation. And inflammation occurs because once these cells in these areas are damaged, they spill their guts. They release a whole range of chemicals that trigger pain.