Using Chemical Stimulation in Mouse Somatic Cells to Induce Pluri Potent Stem Cells

A decade ago work led by hon k dang, who is king university in china, showed that you could use chemicalprogramming to generate pluri potent stem cells. But none of these approaches were able to be translated to induce human cleary potent stem cells from sematic cells. So it was reasoned that there was perhaps a more plastic state than existed in other animals, or in other celllines, under different conditions. And so dangs group here hypothesise that they could recreate that plastic state in human cells and effect that chemic programming. By creating this intermediate plastic state, notably by inhibition of the junk pathway, they were able to create cells that exhibited key features of embryonic stem