Guests:

Dr. Carl June is the Richard W. Vague Professor in Immunology at the University of Pennsylvania, Director of the Center for Cellular Immunotherapies at the Perelman School of Medicine, and Director of the Parker Institute for Cancer Immunotherapy. Dr. Philipp Rommel is a Postdoctoral Researcher in the June lab. Together, they are interested in lymphocyte biology, with a major translational focus on ex vivo T cell engineering for cancer and HIV cell-based therapies.

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The Immunology Science Round Up

Pooled CRISPR Screening Identifies m⁶A RNA as a Regulator of Macrophage Activation – Scientists identified METTL3-mediated m⁶A modification in innate immune responses suggesting the m⁶A machinery could be a target for immunotherapy.

Natural Killer Receptors Fine-Tune T Cells – Researchers identified a role for natural killer cell receptor signaling in regulating self/non-self discrimination by HLA-E–restricted T cells.

Notch4 Signaling in Viral Infections – Notch4 expression on T_reg cells suppressed the induction of amphiregulin and promoted severe lung inflammation in viral infections.

Synthetic Notch CAR T Cells Targeting Solid Tumors in Mice – Scientists developed synthetic Notch CAR T cells targeting solid tumor antigens and used them to treat mouse models of mesothelioma, ovarian cancer, and glioblastoma.

Photo Reference: Courtesy of Drs. Carl June and Philipp Rommel