Understanding Autoimmune Resilience and Gut Health

93% of people are metabolically unhealthy, and it’s not because they’re lazy or eating too much fat. It’s because their bodies forgot how to burn fat at all. This episode gives you a complete roadmap to reboot your metabolism, escape the sugar-burning trap, and reignite your fat-burning engine for good. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Ben Azadi, functional health expert, best-selling author of Metabolic Freedom, and one of today’s most trusted voices in the ketogenic and fasting space. After reversing his own obesity through biohacking and functional medicine, Ben has helped millions unlock metabolic flexibility and master human performance through smarter-not-harder strategies. 

They explore how high insulin, not fat or salt, drives most chronic disease, and why your doctor probably isn’t testing for it. You’ll learn the truth about seed oils, fructose, and blood sugar spikes, and why most people using continuous glucose monitors are still missing the real metabolic threat. 

You’ll also discover how to: 

• Switch out of sugar-burning mode and back into fat-burning ketosis 

• Use fasting, cold therapy, and sleep optimization to repair mitochondrial damage 

• Fix hidden nutrient deficiencies with the right supplements, potassium, and electrolytes 

• Build real metabolic resilience with Danger Coffee, functional medicine, and nootropics 

• Avoid the trap of endless keto or carnivore and learn how to cycle your way to true metabolic freedom 

• Understand why low HRV, high insulin, and sleep debt crush longevity, energy, and brain optimization 

• Decode how neuroplasticity, emotional regulation, and resilience all connect to metabolism 

This is your science-backed guide to transforming your energy, losing stubborn fat, and becoming metabolically unstoppable. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. 

SPONSORS: 

- BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 for 20% off your first order of PerfectAmino.  

- IGNITON | Save 10% at https://endlss.io/sl/igniton/daveasprey.

Resources:  

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• Ben’s New Book - Metabolic Freedom: A 30-Day Guide to Restore Your Metabolism, Heal Hormones & Burn Fat: https://www.amazon.com/Metabolic-Freedom-Restore-Metabolism-Hormones/dp/1401994369 

• Ben’s Instagram: https://www.instagram.com/thebenazadi/?hl=en 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

Timestamps: 

• 00:00 Trailer 

• 01:04 Intro 

• 02:42 Insulin Explained 

• 06:00 Salt vs. Potassium 

• 08:10 Uric Acid & Fructose 

• 12:56 Health Trolls 

• 18:14 Seed Oil Truth 

• 24:24 Cooking Oil Breakdown 

• 31:08 Carnivore & Flexibility 

• 34:57 Gut Test Insights 

• 36:09 Cholesterol Panel 

• 36:43 LMHR Explained 

• 37:39 Inflammation Markers 

• 40:25 Managing Autoimmunity 

• 42:07 Gut Bacteria & Fiber 

• 46:55 Fasting for Gut Health 

• 48:03 Saturated Fat & Gut 

• 49:34 Oxalates & Diet 

• 57:32 Metabolic Efficiency 

• 01:03:08 Hormesis & Stress 

• 01:08:21 Final Takeaways 

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