There are some individuals who have gene up regulation of this particular protein and that could also maybe predisposed them. Is angiotensinogen Constitatively activated what that means is it Constant or a housekeeping? Protein that's always being made and released or does it need to be made and released in response to the random production My understanding is it's always in your blood. Okay, so it's always being released. I think there are some situations where Maybe I could have this wrong, but I think in Nefrotic syndrome where you're losing a lot of proteins and your liver has to make up up them A whole lot of other proteins get made alongside them Right like gamma goblins