Re‑engineering the Immune System for Longevity

AI is transforming medicine at a speed never seen before. In this episode, you’ll discover how digital twins and artificial intelligence will revolutionize drug discovery, eliminate human trials, and personalize your biology for longevity and high performance. Host Dave Asprey breaks down how AI can now simulate virtual cells and tissues, running clinical experiments in minutes instead of years to create truly individualized medicine. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Dr. Derya Unutmaz is a world-renowned immunologist, systems biologist, and professor at The Jackson Laboratory. With more than 150 scientific papers, he’s a leading expert in immune system research and one of the first scientists to pioneer the concept of digital twins for biology. His groundbreaking work uses AI to model how immunity, metabolism, and aging interact—creating new possibilities for personalized medicine, disease prevention, and lifespan extension. 

Host Dave Asprey and Dr. Unutmaz reveal how AGI will soon outperform doctors, accelerate functional medicine, and optimize human biology far beyond today’s standards. You’ll learn how the immune system drives inflammation and aging, how to re-engineer it for resilience, and why compounds like GLP-1 and metformin may add years to your life. 

You’ll Learn: 

• How digital twins will end human drug testing 

• Why AGI could replace doctors and computer jobs within five years 

• How AI models immune function, metabolism, and aging 

• The role of mitochondria and inflammation in longevity 

• How GLP-1 drugs and metformin extend lifespan 

• What continuous biological monitoring means for health tracking 

• How AI is transforming functional medicine and personalized care 

• Why NAD and energy metabolism are key to human performance 

They explore how artificial intelligence, biohacking, and systems biology intersect to create a smarter approach to health and longevity. You’ll also learn how understanding immune balance, metabolism, and mitochondrial function helps build resilience and extend your lifespan. 

This is essential listening for anyone serious about biohacking, hacking human performance, and extending longevity through personalized medicine, functional biology, and cutting-edge AI innovation. 

This is essential listening for anyone serious about biohacking, hacking human performance, improving mobility, and extending longevity. You’ll also learn how neuroplasticity, metabolism, and brain optimization all connect to the way you move. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: AI medicine, Digital twins, Functional medicine, Biohacking, Longevity, Immune system, Inflammation, Personalized medicine, GLP-1 therapy, Metformin, NAD boosters, Mitochondrial function, Metabolism, AGI, Clinical trials, Human performance, Aging research, Systems biology, Immunology, Smarter Not Harder 

Thank you to our sponsors!  

• BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. 
• MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order. 
• Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order.  
• ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order 

Resources:  

• Keep up with Derya’s work: https://x.com/derya_?lang=en 

• Business of Biohacking Summit | Register to attend October 20-23 in Austin, TX https://businessofbiohacking.com/ 

• Danger Coffee: https://dangercoffee.com/discount/dave15 

• Dave Asprey’s BEYOND Conference: https://beyondconference.com 

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated 

• Upgrade Collective: https://www.ourupgradecollective.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen: https://40yearsofzen.com 

Timestamps: 

00:00 — Trailer 

01:25 — Intro 

02:26 — AI’s Role in Extending Lifespan 

02:56 — Regulatory Frameworks and Medical Adoption 

05:19 — Problems with the Immune System 

08:19 — Chronic Fatigue and Long COVID Research 

10:32 — Modern Testing and Multi-Omic Analysis 

14:07 — Personal Longevity Strategy and Supplements 

15:17 — Understanding Exhausted Cells 

23:43 — Personalization in Medicine and AI Analysis 

31:35 — Longevity Escape Velocity 

36:13 — AI Doctors and Prescriptions 

39:55 — Data Quality Concerns in AI Training 

43:19 — The Future of Wearable Technology 

45:50 — Revolutionizing Education with AI 

49:04 — The Future of Higher Education 

52:03 — Future of Work and AI Agents 

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