The Channelers went where no nephrology podcasters have gone before, recording in front of a live audience at the National Kidney Foundation Clinical Meeting in Austin. We had all eight Channelers doing a live podcast.
We did a Freely Filtered-inspired draft of the best diuretics.
The draft order:
Leticia Rolon
Anna Gaddy
Joel Topf
Roger Rodby
Josh Waitzman
Amy Yau
JC Velez
And Melanie Hoenig
References
JC
Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kidney Disease
Intravenous conivaptan for the treatment of hyponatraemia caused by the syndrome of inappropriate secretion of antidiuretic hormone in hospitalized patients: a single-centre experience
Rapidity of Correction of Hyponatremia Due to Syndrome of Inappropriate Secretion of Antidiuretic Hormone Following Tolvaptan
Tolvaptan, a Selective Oral Vasopressin V2-Receptor Antagonist, for Hyponatremia
Josh
Review on amiloride development https://pubmed.ncbi.nlm.nih.gov/7039345/
Toad bladder: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1351665/
Amiloride derivatives that inhibit flagella: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544414/
Amiloride as taste sensor: https://www.science.org/doi/10.1126/science.6691151
Batlle on diabetes Insipidus: https://www.nejm.org/doi/full/10.1056/NEJM198502143120705?query=recirc_curatedRelated_article
Amiloride + ddavp for DI https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518801/
Amy
Treatment of refractory congestive heart failure and normokalemic hypochloremic alkalosis with acetazolamide and spironolactone.
Acetazolamide reversibly inhibits water conduction by aquaporin-4
Inhibition of Human Aquaporin-1 Water Channel Activity by Carbonic Anhydrase Inhibitors
Acetazolamide Attenuates Lithium-Induced Nephrogenic Diabetes Insipidus
Acetazolamide in Lithium-Induced Nephrogenic Diabetes Insipidus
In Vivo Antibacterial Activity of Acetazolamide
Roger
50th anniversary of aldosterone
Joel
Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure
The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial
Effects of Early Empagliflozin Initiation on Diuresis and Kidney Function in Patients With Acute Decompensated Heart Failure (EMPAG-HF)
Empagliflozin and Heart failure: Diuretic and Cardiorenal Effects
Anna
Clinical Results of Treatment of Diabetes Insipidus with Drugs of the Chlorothiazide Series
Treatment of nephrogenic diabetes insipidus with hydrochlorothiazide and amiloride
Influence of renal nerves and sodium balance on the acute antidiuretic effect of bendroflumethiazide in rats with diabetes insipidus
Antidiuretic effect of hydrochlorothiazide in lithium-induced nephrogenic diabetes insipidus is associated with upregulation of aquaporin-2, Na-Cl co-transporter, and epithelial sodium channel
Major Outcomes in High-Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Blocker vs Diuretic
Walsh AC, Moyes A. Intractable Congestive Heart Failure Successfully Treated With Southey Tubes. Can Med Assoc J. 1964 Jun 13;90(24):1375-6.
Godwin TF, Gunton RW. Clinical trial of a new diuretic, furosemide: comparison with hydrochlorothiazide and mercaptomerin. Can Med Assoc J. 1965 Dec 18;93(25):1296-300.
Gerber JG. Role of prostaglandins in the hemodynamic and tubular effects of furosemide. Fed Proc. 1983 Apr;42(6):1707-10.
Schlatter E, Salomonsson M, Persson AE, Greger R. Macula densa cells sense luminal NaCl concentration via furosemide sensitive Na+2Cl-K+ cotransport. Pflugers Arch. 1989 Jul;414(3):286-90. doi: 10.1007/BF00584628.
