How do plasmalogens affect membrane fluidity and signaling?

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In this Metabolic Classroom lecture, Dr. Bikman explains the crucial role of plasmalogens—a unique type of fat found in the membranes of cells, especially in metabolically active tissues like the brain, heart, and fat cells.

These special fats help keep cells flexible, support insulin signaling, protect against oxidative stress, and even regulate energy production by stabilizing mitochondria. Dr. Bikman details how plasmalogens act as “sacrificial shields” to defend cells from damage and how they enable cell signaling by keeping membranes fluid.

Ben explores how plasmalogens directly impact fat cell behavior, enabling white fat to transform into more metabolically active beige fat. This shift enhances fat burning and improves insulin sensitivity. In fat cells and mitochondria alike, plasmalogens influence thermogenesis, mitochondrial efficiency, and even gene expression related to fat storage and breakdown. Dr. Bikman also highlights how lower plasmalogen levels are linked with obesity, diabetes, and other metabolic disorders.

The lecture then connects plasmalogens to insulin signaling, showing how they support proper insulin receptor function through membrane fluidity and lipid raft formation. Without enough plasmalogens, insulin signaling is impaired, leading to elevated blood sugar and higher disease risk.

Finally, he provides actionable steps to support plasmalogen levels through diet and supplements, including DHA-rich foods, alkylglycerol from shark liver oil, and even prebiotic fibers like inulin.

Show Notes/References:

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IMPORTANT NOTE: The information presented is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Dr. Bikman is not a clinician—and, he is not your doctor. Always seek the advice of your own qualified health providers with questions you may have regarding medical conditions.

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