Navigating Treatment Controversies in Metastatic RCC

This chapter explores the contentious role of cytoreductive nephrectomy in metastatic renal cell carcinoma, contrasting historical views with emerging therapeutic options that may lessen surgical necessity. It highlights the intricacies of treatment selection, patient characteristics, and the effectiveness of traditional protocols while discussing the implications of novel therapies and FDA approvals. The conversation emphasizes the need for innovative clinical trials and the complexities surrounding subsequent line treatments in advanced RCC management.