The p53 protein, often called the “guardian of the genome,” is crucial for preventing cancer by repairing damaged DNA or triggering cell death in cells that cannot be repaired. However, in about half of all cancers, the p53 gene is mutated, making the protein ineffective. A groundbreaking study has introduced PG3, a new compound that restores tumor suppression without relying on p53, offering a new option to treat resistant cancers.
Published in Oncotarget on September 17, 2024, the study titled “Integrated stress response (ISR) activation and apoptosis through HRI kinase by PG3 and other p53 pathway-restoring cancer therapeutics,” introduces PG3, a small molecule with a completely new approach to treating cancer. This groundbreaking research was conducted by Dr. Xiaobing Tian and Oncotarget Editor-in-Chief Dr. Wafik S. El-Deiry from Brown University.
The researchers tested PG3 on cancer cell lines with various p53 mutations, as well as on cells that lacked p53 entirely.
Full blog - https://www.oncotarget.org/2024/12/18/a-new-path-to-tumor-suppression-the-promise-of-pg3/
Paper DOI - https://doi.org/10.18632/oncotarget.28637
Correspondence to - Wafik S. El-Deiry - wafik@brown.edu
Video short - https://www.youtube.com/watch?v=eBp_UGrkii8
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Keywords - cancer, mutant p53, integrated stress response (ISR), ATF4, HRI, ClpP
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