In this episode we discuss:
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Why glucose and fructose are not the primary drivers of AGE formation
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Whether blood sugar spikes cause glycation
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How fats and ketones can cause glycation
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What’s really responsible for glycation in type 2 diabetes
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Whether fructose causes more glycation than glucose
Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/
Click here to check out the show notes:
https://www.jayfeldmanwellness.com/eb-137-what-really-causes-glycation-is-sugar-really-the-problem/
Timestamps:
0:00 – intro
0:46 – common beliefs about carbohydrates and glycation
2:35 – what are glycation and advanced glycation end products?
6:57 – the process of glycation from glucose
9:30 – is sugar the only source of AGEs?
15:00 – primary drivers of glycation: dicarbonyls
19:30 – how fatty acids, amino acids, and ketones cause AGE formation
21:23 – how increased gluconeogenesis on low-carb diets increases AGE formation
22:53 – glucose metabolism produces very few glycation products in the context of a healthy metabolism
25:33 – omega-6s form AGEs more than 10x faster than glucose
28:24 – the role of ALEs (advanced lipoxidation end products) in glycation and chronic disease
30:36 – whether blood sugar spikes cause glycation
38:52 – whether fructose causes more glycation (or fructation) than glucose
47:05 – can glycation from fructose (fructation) be measured, and does this matter?
52:06 – problems with research looking at fructose’s AGE formation in animal models
