Low testosterone is sabotaging your health, motivation, and longevity. Diet alone will not fix it.

In this episode of The Human Upgrade, Dave Asprey sits down with Shalin Shah, CEO of Marius Pharmaceuticals, to expose the truth about testosterone decline in both men and women. They break down why testosterone is crashing worldwide, why natural fixes almost always fail, and how the latest science finally makes testosterone therapy safer, simpler, and more effective than ever before.

You will discover why testosterone is essential for dopamine, brain function, sleep, muscle, libido, and mitochondrial health. Fixing your levels can reverse fatigue, brain fog, poor motivation, and slow aging itself.

Shalin reveals how new oral testosterone technology (Kyzatrex®) overcomes the dangers of old therapies and restores natural hormone rhythms without needles, creams, or dangerous side effects.

What You Will Learn in This Episode:

• Why testosterone matters for men and women at every age

• The real causes of the global testosterone crash

• Why diet, sleep, and exercise cannot fully fix low testosterone

• How testosterone drives dopamine, motivation, and longevity

• The breakthrough that makes oral testosterone safe and effective

• How Kyzatrex® lowers SHBG and boosts free testosterone naturally

• Why maintaining youthful testosterone levels protects brain, muscle, libido, and lifespan

• How to safely use testosterone therapy without suppressing fertility or causing side effects

** Visit livethrive.co/asprey to get a discount on your first month's supply! **

Resources:

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

• Purchase Kyzatrex® – https://livethrive.co/?utm_campaign=11813552-Asprey

• Shalin’s Instagram - https://www.instagram.com/themetabolicceo/

• 2025 Biohacking Conference: https://biohackingconference.com/2025

• Danger Coffee: https://dangercoffee.com

• Dave Asprey’s Website: https://daveasprey.com

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com

• Own an Upgrade Labs: https://ownanupgradelabs.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com

Timestamps:

00:00 Trailer

00:52 Introduction

01:29 Global Decline in Testosterone Levels

02:27 Symptoms of Low Testosterone

03:48 Personal Journey with Testosterone Therapy

05:06 The Role of Testosterone in Overall Health

06:18 Testosterone Levels in Men and Women

08:48 Challenges and Innovations in Testosterone Delivery

16:25 The Importance of Circadian Rhythm in Testosterone Therapy

19:19 The Future of Testosterone Therapy

32:00 Investment and Development in Testosterone Therapy

34:57 Introduction to FDA and Hormone Replacement

35:31 FDA’s Impact on Women’s Health

36:10 Testosterone and Cardiovascular Risk

39:05 Testosterone and Depression

40:30 Testosterone Testing and Misconceptions

44:58 The Testosterone Project and Female Hormone Therapy

47:51 Testosterone’s Role in Longevity and Health

55:37 Cost and Accessibility of Testosterone Therapy

01:04:03 Conclusion and Final Thoughts

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