Navigating Pediatric Respiratory Trials

This chapter explores the Paris 2 trial, which compares high flow nasal oxygen to standard therapy for children with acute hypoxic respiratory failure. The discussion includes the evolution of high flow nasal cannula use, challenges in rural settings, and critiques of study methodologies and health outcome measures. Emphasizing a preference for patient-centered outcomes, it raises critical questions about the necessity of advanced equipment in pediatric care.