HMMA Venetoclax and A's Event

HMMA Venetoclax was effective regardless of you know for example P53 status etc. Can you kind of explain that a little bit because it still seems like you have higher response rates in these patients. In P53 mutant patients particularly with the varantilial frequency is above 10% and particularly if they have adverse chromosomes the benefit of A's event compared to A's is very minimal. So I think in every case except for P53 mutations there's no hesitation to use A's event but for people with mutations it's still pretty unclear.