Inflammation is at the center of many of today's most common chronic diseases — but what if the real starting point isn't where most people think?

In this episode of The Exam Room Podcast, host Chuck Carroll is joined by gastroenterologist and best-selling author Dr. Will Bulsiewicz for a wide-ranging and deeply human conversation about gut health, chronic inflammation, and the hidden role that stress, loneliness, and modern lifestyle play in making us sick.

Drawing from his new book Plant-Powered Plus, Dr. Bulsiewicz explains why the gut is a central command center for the immune system and the brain, and how dysfunction in the microbiome can drive everything from digestive distress to depression, anxiety, and long-term disease. He also opens up about his own personal health journey — including burnout, weight gain, and metabolic illness — and how healing his gut transformed both his life and his medical practice.

This episode goes beyond food to explore the science of the brain-gut-immune connection, the impact of chronic stress and isolation on inflammation, and why true healing requires more than just changing what's on your plate. If you've ever felt successful on the outside but unwell on the inside, this conversation offers clarity, compassion, and hope.

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