2min chapter

#188: Dom D'Agostino on Disease Prevention, Cancer, and Living Longer

The Tim Ferriss Show

notes

CHAPTER

Metformin and Calorie Restriction

Metformin is a pretty powerful activator of amp kinase. It may lower end-tore signaling, etc. So it does, all these things are things that calorie restriction do. We think that the benefits of calorie restriction are likely mediated by some of the things that I mentioned and undoubtedly there's many other things that are also happening.

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Transcript

Episode notes

Dr. Dominic "Dom" D'Agostino (@DominicDAgosti2) is one of my most popular guests, and I'm happy to have him rejoin the show for the third time. (You can listen to Dom's first appearance here, and his second appearance here). Dom is an assistant professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine, and a senior research scientist at the Institute for Human and Machine Cognition (IHMC) -- which is mentioned in the current issue of Outside Magazine (on which there's a clown who looks a lot like me). Much of Dom's work is related to metabolic therapies and nutritional strategies for peak performance and resilience in extreme environments. Dom's research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), and other private organizations and foundations. In this episode, Dom focuses on disease prevention, cancer, and more mastery of the ketogenic diet. Please enjoy this tutorial and masterclass with Dominic D'Agostino. Show notes and links for this episode can be found at www.fourhourworkweek.com/podcast. This podcast is brought to you by Vimeo Business. Vimeo Business has all of the prior benefits of Vimeo Pro, including VIP support. Whether you make videos for a living, run your own company, or simply want to amp up your video marketing, Vimeo Business is here to help. It has more than 280 million creators and viewers worldwide and makes it easier to share your videos with a global audience and connect with professional video makers to bring your stories to life. Vimeo Business allows you to upload up to five terabytes and store your videos in one secure place, add up to 10 team members to your account for easy collaboration, and gather feedback with seamless review tools. You can even add clickable calls to action and capture email addresses directly in the player, which can help you generate leads and drive conversion for whatever you're trying to optimize -- such as a newsletter or a sales page. Check out vimeo.com/tim10 to save 10 percent on Vimeo Business. This podcast is also brought to you by Wealthfront. Wealthfront is a massively disruptive (in a good way) set-it-and-forget-it investing service led by technologists from places like Apple. It has exploded in popularity in the last two years and now has more than $2.5B under management. Why? Because you can get services previously limited to the ultra-wealthy and only pay pennies on the dollar for them, and it's all through smarter software instead of retail locations and bloated sales teams. Check out wealthfront.com/tim, take their risk assessment quiz, which only takes 2-5 minutes, and they'll show you -- for free -- exactly the portfolio they'd put you in. If you want to just take their advice and do it yourself, you can. Well worth a few minutes to explore: wealthfront.com/tim.

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