Peptides or Sarms?

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1. Non-marine Omega 3 Sources [14:25]

Robert says:

Hi Rob and Nicki. I am unable to supplement with fish oil because it severely increases my anxiety and will eventually lead to terrible episodes of panic and OCD. It took me a while to figure out it was the fish oil because you typically only hear about how beneficial it is and all of the positives from supplementation. Because of this I’m worried about getting enough DHA and EPA. I do eat fish about once a week/week and a half. I don’t seem to have the same problem when eating fish but I’m sure I’m not eating it enough to replicate the same problem from supplementing fish oil and I also worry about eating high amounts of fish due to contaminants. I’ve also heard that getting omega 3 from plant sources like flaxseed is insufficient. How can I make sure I’m getting enough DHA and EPA? I’m 33 years old, have been eating low carb for 5 years, lift 4 days a week, I’m very active and fit and a healthy weight. Also any idea why fish oil does this to me? Acetylcholine?

2. How Much (or little) Protein? [18:29]

Hilary says:

I'm so confused about protein. Many very smart scientist wellness leaders say use it as a condiment and low protein intake = longevity. Others believe in leading with abundant animal protein to create strength and muscle which will = longevity. I'm a fit 63 yr old woman and confused about what science to follow. Thank you!

3. SARMs, peptides, & testosterone boosting herbs [25:52]

Jamie says:

Ay up Robb and Nicki,

Ages ago, I sent you a question about ketogenic diets and TBI which you were gracious enough to answer on THR038. I have upped my salt intake as per your answer to that question and it has helped. In the proceeding time I have been doing more research on TBI and I came across the world leader in its treatment, Dr. Mark Gordon. His protocol centres around dampening down the neuroinflammation in the brain and restoring any hormonal imbalances that occur after a TBI. Although I am not 100%, I am definitely better and I just feel that it’s just one or two adjustments that I need to make with the biggest thing, perhaps the only thing holding me back, sleep, or lack of it I should say.

I follow Dr. Mark Gordon’s recommendation of 100mg of pregnenolone before bed and whilst he reports in his clinical practice that for most people this tidies up their sleep, it hasn’t done that for me. Dr Gordon says when this happens he usually prescribes a small dose of progesterone, 5mg, and this usually does the trick. Instead of doing that I wish to try something else as I have come across the world of peptides, some of which I have experimented with. I’ve tried CJC 1290 with DAC and ipamorelin for growth hormone release as well as BPC-157 for tissue and bone repair for some long-term issues I have had with my joints which has actually helped me a little bit. The CJC1290 and ipamorelin didn’t really do much for my sleep but I have found deep sleep-inducing peptide (DSIP) which I have bought but not yet tried. I have also come across SARM’s, (selective androgen reuptake modulators) which I haven’t tried. They come with some pretty stunning claims to be made on both their benefits and lack of side effects. What is your take on peptides and SARM’s? Would their long-term use turn off someone’s own endogenous production in the same way that exogenous testosterone does?

Instead of SARM’s, which I am sceptical of being able to do the job of replenishing the role of testosterone in my brain, I am instead doing clomid, 50mg every third day, and also Dan Huberman’s recommendation of using the herbs Fadogia Agrestis and Tongkat Ali to help boost testosterone. Would it be worth cycling these herbs, especially Fadogia, as from my understanding it mimics luteinising hormone? Could this then shut off my own endogenous production of luteinising hormone?

Just one final note to make, it’s amazing what you can find and then buy on the Internet, especially when using Bitcoin!?

Thank you

Jamie

4. Muscle Cramping and Salt [35:55]

Ben says:

Hey Robb and Nicki,

Great podcast, I really enjoy and appreciate all you do. I have a question regarding muscle cramping.

It is something I have dealt with for essentially my whole life. My father has had problems with hamstring, calf and hand cramping through his life as well.

Personally, after harder workouts I notice my hamstrings have a very low threshold to cramp, as well as hands and abs. At night, my gastrocs and peroneals cramp as well.

Since starting LMNT and supplementing my own salt to it (~ 6-8g total salt/day) my hamstring, ab, and hand cramps have greatly been improved though my calf cramps still seem to be present. The night time calf cramps fluctuate from 1-2 to 9-10 times/ night requiring I jump out of bed to dorsiflex my foot against the ground to get it to stop. I have tried some "leg cramp" pills from Sprouts which seem to help some but not completely.

Sorry for rambling but lastly I have had my DNA run and it states I "wasted salt" and should add more salt to my diet.

I am wondering if you think I just need to supplement more salt? (Though at times I feel I put too much in and disaster pants is a real thing) or if there may be something bigger that I should see a functional practitioner for? Any insight would be greatly appreciated. Thank you

(For reference, Im a 31 year old male, crossfit 5-6 times/ week and am standing in the OR 3-5 times/ week. 6'4"; 225 lbs. Eat paleo)

5. Importance of Grass fed meat [40:02]

Paul says:

Hi guys

I have a question about grass fed meat and the evidence for its importance for it to be grass fed. Eating meat from healthy well fed, free animals intuitively sounds like a good idea for your health. It also fits with the overall philosophy of paleo eating which I use as my guide through these things.

However Living in Norway sometimes means that is not possible and I have to get my meat from the supermarket.

It  got me wondering about what scientific evidence there is to support the hypothesis that grass fed /organic meat etc is actually better for your health.

So my question is what evidence , if any , have found of this in the literature. If there is evidence are there some animals that are better than others to get from supermarket.I notice myself if eat half a rotisserie chicken from the supermarket i can feel pretty rough after that but half a kilo mince I'm just fine- same with any fish.

Regards

Paul

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