Why does ibuprofen take so long to work?
Chemistry For Your Life
Extended-Release Delivery Research
Melissa describes metal-organic frameworks that kept ibuprofen in mice bloodstream twice as long for potential slow-release uses.
#196
Melissa and Jam delve into the science behind ibuprofen, exploring why it takes around 30 minutes to work. The discussion covers the chemistry of ibuprofen, including the concept of chiral molecules and enantiomers—molecules with mirror-image forms—highlighting how only one form of ibuprofen works effectively. The episode explains why both forms are included in the medication due to production challenges and discusses recent findings about ibuprofen's potential in cancer treatment. Additionally, the show features various fun facts about ibuprofen, aspirin comparisons, environmentally friendly production methods, and more.
00:00 Introduction and Episode Overview
05:07 Chemistry Lesson: Handedness of Molecules
17:52 Ibuprofen's Chiral Nature and Its Effects
19:15 The Racemic Mixture of Ibuprofen
24:06 The Wastefulness of Chemistry
24:29 Challenges of Purifying Enantiomers
25:16 Economic and Environmental Considerations
26:28 Understanding Ibuprofen's Handedness
27:26 The Debate on Enantiomer Separation
34:45 Fun Facts About Ibuprofen
39:55 Green Chemistry and Ibuprofen
45:42 Community and Closing Remarks
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276492/
- https://thispodcastwillkillyou.com/wp-content/uploads/2021/07/TPWKY-Episode-29-Aspirin.pdf
- https://www.chemistryworld.com/podcasts/ibuprofen/4011375.article
- https://pubs.acs.org/doi/epdf/10.1021/bi010045s?ref=article_openPDF
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355401/ 6. Garret & Grisham Biochemistry Textbook
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