Hormone Replacement Therapy in Men

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When people hear HRT, they think about super physiological seems to be the term. I've never seen a single symptom in a single woman that I've put testosterone on in terms of like acne, body hair, things like that. But you know, like, clitoral enlargement and things like that, like that doesn't happen under physiologic normal conditions. That said, just like with depression and antidepressants, there is a kind of a cliff after which low enough testosterone or low enough serotonin prevents people from sleeping exercise, social connection, et cetera.

My guest this episode is Dr. Peter Attia, M.D., who trained at Stanford University School of Medicine, Johns Hopkins Hospital and the National Institutes of Health (NIH). Dr. Attia is host of The Drive podcast and is a world expert on behavioral approaches, nutritional interventions, supplementation and pharmacological techniques to improve lifespan, healthspan and athletic performance. We discuss how best to evaluate your health status using routine blood work, body scans and regular tests of physical strength and endurance. Dr. Attia explains what he uses with his patients to “back-cast” their health goals as a way to design their exercise and nutritional programs. We also discuss hormone modulation and replacement therapy for both men and women. We explain how cholesterol and related factors contribute to cardiovascular disease risk and how to monitor and mitigate that risk. Dr. Attia details various supplementation, nutrition, exercise and prescription approaches useful to people in every decade of life to improve vitality, reduce their risk of disease and increase the number of years sustaining peak cognitive and physical health.

For the full show notes, visit hubermanlab.com.

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Timestamps

(00:00:00) Assessing Health Status & Improving Vitality

(00:03:07) Sponsors: AG1, LMNT

(00:07:29) Lifespan: Bloodwork & Biomarkers Testing, The “4 Horseman of Disease”

(00:11:51) Healthspan: Functional Testing, Cognitive & Emotional States

(00:13:59) Blood Testing: Best Frequency

(00:16:01) DEXA Scan: Lean Mass & Fat, Bone Mineral Density & Osteoporosis

(00:22:33) Bone Mineral Density & Age-Related Decline, Strength Training, Corticosteroids

(00:29:24) Osteopenia & Osteoporosis Diagnosis, Strength Training

(00:29:52) Sponsor: AG1

(00:32:16) Back-casting: Defining Your “Marginal Decade”

(00:38:31) All-Cause Mortality: Smoking, Strength, VO2 max

(00:44:43) Attia’s Rule of Supplementation, “Centenarian Decathlete” Physical Goals

(00:49:24) Importance of Exercise, Brain Health, MET hours

(00:55:23) Nicotine & Cognitive Focus

(01:03:12) Menstruation, PMS & Menopause

(01:10:10) Hormone Replacement Therapy, Menopause & Breast Cancer Risk

(01:22:06) Estrogen, Progesterone & Testosterone Therapies in Women

(01:26:35) Hormone Replacement Therapy in Men, SHBG & Testosterone, Insulin

(01:37:23) Clomid, Pituitary, Testosterone & Cholesterol, Anastrozole, HCG

(01:47:46) Fadogia Agrestis, Supplements, Rapamycin

(01:52:06) Testosterone Replacement Therapy & Fertility

(01:59:26) Total Testosterone vs. Free Testosterone

(02:02:51) Cholesterol & Dietary Cholesterol, Saturated Fat, LDL & HDL, Apolipoprotein B

(02:17:42) Apolipoprotein B, Diet, Statins & Other Cholesterol Prescriptions

(02:25:15) Cardiovascular Disease, Age & Disease Risk

(02:28:53) Peptides, Stem Cells, BPC157, PRP (Platelet-Rich Plasma), Injury Rehabilitation

(02:37:40) Metabolomics & Exercise

(02:40:44) GLP-1 & Weight Loss

(02:47:06) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter, Huberman Lab Clips

Title Card Photo Credit: Mike Blabac

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