Oncotarget’s cover paper this week (Volume 12, Issue 16) is entitled, "Epigenetic signatures differentiate uterine and soft tissue leiomyosarcoma," by researchers from Yale University School of Medicine, New Haven, CT.
“In this study, we performed a comprehensive analysis and compared the DNA methylation and RNA expression profiles of ULMS and STLMS samples from the TCGA-SARC study.”
First, the team identified two LMS subtypes based on their site of origin: uterine LMS (ULMS) and non-uterine soft tissue LMS (STLMS). Next, they compared their molecular landscapes using The Cancer Genome Atlas-Sarcoma (TCGA-SARC) dataset and comprehensively analyzed 27 ULMS and 53 STLMS samples. Researchers assessed for epigenetic and transcriptomic differences between ULMS and STLMS. They hoped these differences would help identify differentially methylated genes and differentially expressed genes (DEGs) in these LMS subtypes. Findings from the TCGA-SARC dataset were then compared to two independent DNA methylation datasets, GSE140686 and GSE68312.
“In this study, we performed an integrated analysis of 98 clinically derived LMS samples and 11 controls using three publicly available datasets to identify epigenetic changes which characterize LMS subtypes and may be used as clinical biomarkers and therapeutic targets.”
Datasets were then used in comparative DNA methylation analysis to compare controls with the identified epigenetic changes associated with tumorigenesis. Network and pathway analysis were performed to further characterize the differential transcription signatures between ULMS and STLMS.
Full blog - https://www.oncotarget.org/2021/08/04/epigenetic-signatures-differentiate-leiomyosarcoma-subtypes/
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DOI - https://doi.org/10.18632/oncotarget.28032
Full text - https://www.oncotarget.com/article/28032/text/
Correspondence to - Nita Ahuja - nita.ahuja@yale.edu
Keywords - leiomyosarcoma, epigenetics, DNA methylation, gene expression, uterine leiomyosarcoma
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